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Experimental treatment pushed by ALS patients gets day before FDA, but agency unconvinced it works

Published Fri, 15 Nov 2024 01:18:29 GMT

By MATTHEW PERRONE (AP Health Writer)WASHINGTON (AP) — The Food and Drug Administration meets this week to consider approval of an experimental treatment for Lou Gehrig’s disease, the culmination of a yearslong lobbying effort by patients with the fatal neurodegenerative disease.Those advocates still face one giant hurdle: FDA regulators say the treatment hasn’t been shown to work.In documents posted Monday, the FDA reiterated its longstanding position that a lone study by drugmaker Brainstorm doesn’t provide convincing evidence that its stem cell-based therapy helps patients with ALS, or amyotrophic lateral sclerosis.It’s the same message the FDA delivered to company executives in early 2021 when they first shared data on the treatment, dubbed NurOwn. And again last November, when the FDA refused to accept the company’s application for review.But with the backing of thousands of ALS patients, Brainstorm took the rare step of “filing over pr...

Malibu Farm opens at Seaport Village

Published Fri, 15 Nov 2024 01:18:29 GMT

SAN DIEGO -- A new restaurant is serving up farm-to-table dishes at Seaport Village: Malibu Farm.The two-level restaurant has replaced Harbor House, which served tourists and locals for 40 years. Renovations on the restaurant began in 2020.While the lower level is an event space that can be reserved for private dining, the upper level is open to the public.Its menu features a chicken ricotta bacon burger and coconut ceviche -- made either vegan or with cod -- served in a coconut shell bowl. Winning $5.4 million Powerball ticket sold in Southern California "Right now, we're going with a lot of our specials from all of the locations, but we're working with local farmers and we'll roll out some San Diego original dishes in a couple of weeks," co-owner Helene Henderson said to FOX 5 on Monday.The full bar features specialty cocktails like the "papaya," which consists of papaya strawberry-infused blanco tequila, organic agave, fresh lime juice and lava sea salt, and the "tomato" -- vod...

Crown withdraws charges against construction company in fatal Barrie crash

Published Fri, 15 Nov 2024 01:18:29 GMT

Criminal charges against a construction company in a crash north of Toronto that killed six young people have been withdrawn by the Crown.Defence lawyer Marie Henein says all six counts of criminal negligence causing death against Condrain Group in the August 2022 crash were withdrawn Monday.Police have said the victims, all in their early 20s, were heading to a casino north of Toronto around 6 a.m. when their car crashed in a construction site, killing everyone in the vehicle.Investigators had determined that the crash happened at a municipal construction site on a rural road, where the car plunged into a deep pit nearly 24 hours before police officers came across the scene.Family and friends identified those killed in the crash as Curtis King, 22; River Wells, 23; Jason Ono-O’Connor, 22; Luke West, 22; Jersey Mitchell, 20; and Haley Marin, 21.The Concord, Ont.-based Condrain Group says in a written statement that it always had confidence in the justice system, adding it rema...

This story by The Canadian Press is no longer available.

Published Fri, 15 Nov 2024 01:18:29 GMT

GATINEAU, Que. — This story is no longer available.The Canadian Press

Here’s when your favorite show may return as writers strike is on the verge of ending

Published Fri, 15 Nov 2024 01:18:29 GMT

LOS ANGELES (AP) — A tentative agreement between striking screenwriters and Hollywood studios offers some hope that the industry’s dual walkouts may soon be over. But when will your favorite shows return?Well, it’s complicated. First, the agreement needs to pass two key votes, and certain paused productions such as “Deadpool 3” and “Yellowjackets” will still have to wait on actors to reach a deal with studios.WHEN IS ‘JIMMY KIMMEL LIVE’ COMING BACK?Once the contract is approved, work will resume more quickly for some writers than others. Late-night talk shows were the first to be affected when the strike began, and they may be among the first to return to air now. NBC’s “The Tonight Show Starring Jimmy Fallon,” ABC’s “Jimmy Kimmel Live” and “The Late Show With Stephen Colbert” on CBS could come back within days.“Saturday Night Live” might be able to return for its 49th season, though some actors may not be able to appear. The actors strike limits promotional appearances ...

US and Kenya sign defense agreement ahead of planned Haiti deployment

Published Fri, 15 Nov 2024 01:18:29 GMT

NAIROBI, Kenya (AP) — The U.S. and Kenya signed a defense agreement Monday that will see the East African nation get resources and support for security deployments as it is poised to lead a multi-national peacekeeping mission to Haiti to combat gang violence.U.S. Defense Secretary Lloyd Austin and Kenya’s Defense Minister Aden Duale signed the accord at a meeting in the Kenyan capital, Nairobi. The agreement guides the countries’ defense relations for the next five years as the war in East Africa against the al-Qaeda linked al-Shabab extremist group intensifies.Austin thanked Kenya for volunteering to take the leadership of the Haiti multi-national force and reiterated that the U.S government would work with Congress to secure the $100 million in funding that it pledged on the sidelines of the U.N General Assembly.Austin said the rest of the world ought to follow Kenya’s commitment to global security and “step up and provide more personnel, equipment, support, training and fun...

Texas Walmart shooter agrees to pay more than $5M to families over 2019 racist attack

Published Fri, 15 Nov 2024 01:18:29 GMT

AUSTIN, Texas (AP) — A white Texas gunman who killed 23 people in a racist attack on Hispanic shoppers at a Walmart in 2019 agreed Monday to pay more than $5 million to families of the victims.Patrick Crusius was sentenced to 90 consecutive life sentences in July after pleading guilty to federal hate crime charges following one of the nation’s worst mass killings. U.S. District Judge David Guaderrama signed off on the amount that Crusius must pay in restitution. Crusius still faces a separate trial in a Texas court that could end with him getting the death penalty.Police say Crusius drove more than 700 miles from his home near Dallas to target Hispanics with an AK-style rifle inside and outside the store. Moments before the attack began, Crusius posted a racist screed online that warned of a Hispanic “invasion” of Texas.Paul J. Weber, The Associated Press

Milan fashion celebrated diversity and inclusion with refrain: Make more space for color, curves

Published Fri, 15 Nov 2024 01:18:29 GMT

MILAN (AP) — More curvy models than ever showed up on Milan runways this season, due mostly to a single show by Brazilian designer Karoline Vitto, while designers of color showcased their work at collateral events meant to promote their visibility — along with diversity — in the backrooms of Italian fashion.Wherever diversity and inclusion were being celebrated during Milan Fashion Week, which ended Sunday, there was one underlying refrain: Make more space. CURVY MODELS GET OUTING AT KAROLINE VITTO“We made history! It was incredible,’’ world-renown curvy model Ashley Graham gushed as she embraced London-based Vitto after Sunday’s show. Graham is often the only curvy model on major fashion runways, but for this show she led a cast of models ranging in size from UK 10 to UK 24 (US 6 to US 20).By comparison, some Milan brands typically size up to 48 Italian (US size 12), while some, notably Dolce & Gabbana which sponsored Vitto, has extended some looks up to an Italian size 52 (US ...

US-backed Kurdish forces impose curfew in eastern Syria after new clashes with rival Arab militia

Published Fri, 15 Nov 2024 01:18:29 GMT

BEIRUT (AP) — U.S.-backed Kurdish-led forces imposed a curfew after clashes erupted again on Monday in eastern Syria, where their fighters had battled for weeks with rival Arab militiamen, Syrian media and activists reported.The fighting in a region where hundreds of American troops are deployed has pointed to dangerous seams in a coalition that has kept a lid on the defeated Islamic State group for years. The reports say the Syrian Democratic Forces imposed the open-ended measure in several towns in Deir el-Zour province, including the town of Ziban, close to the Iraqi border where the Americans are based. Hundreds of U.S. troops have been there since 2015 to help in the fight against the militant Islamic State group. The oil-rich province is home to Syria’s largest oil fields.Al Mayadeen, a pan-Arab TV station, said several fighters from the Kurdish-led forces were killed after Arab gunmen took over several parts of Ziban on Monday. The SDF in a statement Monday said the gunmen en...

Music Review: Breathy, mid-tempo Wilco returns for ‘Cousin,’ which is heavy on the slower tracks

Published Fri, 15 Nov 2024 01:18:29 GMT

If you like your Wilco mid-tempo, melodic and breathy, then “Cousin” is for you. Taking yet another departure in tone after last year’s epic double album “Cruel Country,” the Chicago combo’s latest is more along the lines of 2019’s “Ode to Joy.” Wilco enlisted Welsh artist Cate Le Bon to produce the 10 tracks on “Cousin,” the band’s 13th studio record. It marked the first time since 2007’s “Sky Blue Sky” that Wilco went outside the band for a producer.The result is a deeply layered, musically rich record, albeit heavy on the slower tracks. At times, like on “Pittsburgh,” the soundscape is so thick it feels like an aural impressionist painting, with layer upon layer of music melded together to create a sonic image.This is music for late at night, with the lights down low, a favorite beverage within reach, and no distractions.“Infinite Surprise” is a standout, leading off “Cousin” slowly and then building to a cacophonous crescendo. But songwriter a...